So far the "Science Wars" have generated far more heat than light. Combatants from one or the other of what C. P. Snow famously called "the two cultures" (science versus the arts and humanities) have launched bitter attacks but have seldom engaged in constructive dialogue about the central issues. In The One Culture?, Jay A. Labinger and Harry Collins have gathered together some of the world's foremost scientists and sociologists of science to exchange opinions and ideas rather than insults. (...) The contributors find surprising areas of broad agreement in a genuine conversation about science, its legitimacy and authority as a means of understanding the world, and whether science studies undermines the practice and findings of science and scientists. The One Culture? is organized into three parts. The first consists of position papers written by scientists and sociologists of science, which were distributed to all the participants. The second presents commentaries on these papers, drawing out and discussing their central themes and arguments. In the third section, participants respond to these critiques, offering defenses, clarifications, and modifications of their positions. Who can legitimately speak about science? What is the proper role of scientific knowledge? How should scientists interact with the rest of society in decision making? Because science occupies such a central position in the world today, such questions are vitally important. Although there are no simple solutions, The One Culture? does show the reader exactly what is at stake in the Science Wars, and provides a valuable framework for how to go about seeking the answers we so urgently need. Contributors include: Constance K. Barsky, Jean Bricmont, Harry Collins, Peter Dear, Jane Gregory, Jay A. Labinger, Michael Lynch, N. David Mermin, Steve Miller, Trevor Pinch, Peter R. Saulson, Steven Shapin, Alan Sokal, Steven Weinberg, Kenneth G. Wilson. (shrink)

Brain dead organ donors are the principal source of transplantable organs. However, it is controversial whether brain death is the same as biological death. Therefore, it is unclear whether organ removal in brain death is consistent with the ‘dead donor rule’, which states that organ removal must not cause death. Our aim was to evaluate the public9s opinion about organ removal if explicitly described as causing the death of a donor in irreversible apneic coma. We conducted a cross-sectional internet survey (...) of the American public (n=1096). Questionnaire domains included opinions about a hypothetical scenario of organ removal described as causing the death of a patient in irreversible coma, and items measuring willingness to donate organs after death. Some 71% of the sample agreed that it should be legal for patients to donate organs in the scenario described and 67% agreed that they would want to donate organs in a similar situation. Of the 85% of the sample who agreed that they were willing to donate organs after death, 76% agreed that they would donate in the scenario of irreversible coma with organ removal causing death. There appears to be public support for organ donation in a scenario explicitly described as violating the dead donor rule. Further, most but not all people who would agree to donate when organ removal is described as occurring after death would also agree to donate when organ removal is described as causing death in irreversible coma. (shrink)

Some patients who have been diagnosed as “dead by neurologic criteria” continue to exhibit certain brain functions, most commonly, neuroendocrine functions. This preservation of neurologic function after the diagnosis of “brain death” or “brainstem death” is an ongoing source of controversy and concern in the medical, bioethics, and legal literatures. Most obviously, if some brain function persists, then it is not the case that all functions of the entire brain have ceased and hence, declaring such a patient to be “dead” (...) would be a false positive, in any nation with so-called “whole brain death” laws. Furthermore, and perhaps more concerning, the preservation of any brain function necessarily entails the preservation of some amount of brain perfusion, thereby raising the concern as to whether additional areas of neural tissue may remain viable, including areas in the brainstem. These and other considerations cast significant doubt on the reliability of diagnosing either “brain death” or “brainstem death.”. (shrink)

Experts often communicate probabilities verbally (e.g., unlikely) rather than numerically (e.g., 25% chance). Although criticism has focused on the vagueness of verbal probabilities, less attention has been given to the potential unintended, biasing effects of verbal probabilities in communicating probabilities to decision-makers. In four experiments (Ns = 201, 439, 435, 696), we showed that probability format (i.e., verbal vs. numeric) influenced participants’ inferences and decisions following a hypothetical financial expert’s forecast. We observed a format effect for low probability forecasts: verbal (...) probabilities were interpreted more pessimistically than numeric equivalents. We attributed the difference to directionality, a linguistic property that biases attention toward an outcome. In the high-probability conditions, the directionality of verbal and numeric probabilities aligned (both were positive), whereas they differed in the low-probability conditions (verbal probabilities were more negative). Participants inferred recommendations congruent with the communicated direction and these inferences mediated the effect of probability format on decisions. (shrink)

Variant Creutzfeldt–Jakob disease is a fatal, transmissible, neurodegenerative disorder for which there is currently no effective treatment. vCJD arose from the zoonotic spread of bovine spongiform encephalopathy. There is now compelling evidence for human to human transmission through blood transfusions from presymptomatic carriers and experts are warning that the real epidemic may be yet to come. Imperatives exist for the development of reliable, non-invasive presymptomatic diagnostic tests. Research into such tests is well advanced. In this article the ethical implications of (...) the availability of these tests are elaborated and comparisons drawn with predictive genetic testing for Huntington’s disease and screening for HIV. Paramount to considerations is the issue of whom to test, weighing up respect for personal autonomy against obligations to benefit and protect society. A paradigm is proposed similar to that used for HIV screening but with unique features: compulsory testing of all blood/organ donors and individuals undergoing surgery or invasive procedures who have a significant risk of disease transmission. (shrink)

It is shown that the Hilbert space formalism of quantum mechanics can be derived as a corrected form of probability theory. These constructions yield the Schrödinger equation for a particle in an electromagnetic field and exhibit a relationship of this equation to Markov processes. The operator formalism for expectation values is shown to be related to anL 2 representation of marginal distributions and a relationship of the commutation rules for canonically conjugate observables to a topological relationship of two manifolds is (...) indicated. (shrink)

In March 1996, the General Accounting Office (GAO) issued the reportScientific Research: Continued Vigilance Critical to Protecting Human Subjects.It stated that “an inherent conflict of interest exists when physician-researchers include their patients in research protocols. If the physicians do not clearly distinguish between research and treatment in their attempt to inform subjects, the possible benefits of a study can be overemphasized and the risks minimized.” The report also acknowledged that “the line between research and treatment is not always cleartoclinicians. Controversy (...) exists regarding whether certain medical procedures should be categorized as research.”This problem currently plagues gene transfer research. A few months prior to the GAO report, an ad hoc committee appointed by National Institutes of Health (NIH) Director Harold Varmus expressed similar concerns in its assessment of NIH investment in research on gene therapy. (shrink)

In March 1996, the General Accounting Office (GAO) issued the reportScientific Research: Continued Vigilance Critical to Protecting Human Subjects.It stated that “an inherent conflict of interest exists when physician-researchers include their patients in research protocols. If the physicians do not clearly distinguish between research and treatment in their attempt to inform subjects, the possible benefits of a study can be overemphasized and the risks minimized.” The report also acknowledged that “the line between research and treatment is not always cleartoclinicians. Controversy (...) exists regarding whether certain medical procedures should be categorized as research.”This problem currently plagues gene transfer research. A few months prior to the GAO report, an ad hoc committee appointed by National Institutes of Health (NIH) Director Harold Varmus expressed similar concerns in its assessment of NIH investment in research on gene therapy. (shrink)

In March 1996, the General Accounting Office issued the report Scientific Research: Continued Vigilance Critical to Protecting Human Subjects. It stated that “an inherent conflict of interest exists when physician-researchers include their patients in research protocols. If the physicians do not clearly distinguish between research and treatment in their attempt to inform subjects, the possible benefits of a study can be overemphasized and the risks minimized.” The report also acknowledged that “the line between research and treatment is not always clear (...) to clinicians. Controversy exists regarding whether certain medical procedures should be categorized as research.”This problem currently plagues gene transfer research. A few months prior to the GAO report, an ad hoc committee appointed by National Institutes of Health Director Harold Varmus expressed similar concerns in its assessment of NIH investment in research on gene therapy. (shrink)

For nearly half a century, Quentin Skinner has been the world's foremost interpreter of Thomas Hobbes. When the contextualist mode of intellectual history now known as the “Cambridge School” was first asserting itself in the 1960s, the life and writings of John Locke were the primary topic for pioneers such as Peter Laslett and John Dunn. At that time, Hobbes was still the plaything of philosophers and political scientists, virtually all of whom wrote in an ahistorical, textual-analytic manner. Hobbes had (...) not been the subject of serious contextual research for decades, since the foundational writings of Ferdinand Tönnies. For Skinner, he was thus an ideal subject, providing a space for original research on a major figure, and an occasion for some polemically charged methodological manifestos. Both of these purposes animated his 1965 article “History and Ideology in the English Revolution,” and his 1966 article “The Ideological Context of Hobbes's Political Thought”. The latter of these remains to this day one of the most widely cited scholarly articles in the fifty-year run of Cambridge's Historical Journal. Among other results of these early efforts was the scholarly controversy during which Howard Warrender chided Skinner for having reduced the “classic texts in political philosophy” to mere “tracts for the times”. (shrink)

Thomas Hobbes and John Locke sit together in the canon of political thought but are rarely treated in common historical accounts. This book narrates their intertwined careers during the Restoration period, when the two men found themselves in close proximity and entangled in many of the same political conflicts. Bringing new source material to bear, In the Shadow of Leviathan establishes the influence of Hobbesian thought over Locke, particularly in relation to the preeminent question of religious toleration. Excavating Hobbes's now (...) forgotten case for a prudent, politique toleration gifted by sovereign power, Jeffrey R. Collins argues that modern, liberal thinking about toleration was transformed by Locke's gradual emancipation from this Hobbesian mode of thought. This book investigates those landmark events - the civil war, Restoration, the popish plot, the Revolution of 1688 - which eventually forced Locke to confront the limits of politique toleration, and to devise an account of religious freedom as an inalienable right. (shrink)

Dr. Gary R. Collins provides an overview and evaluation of the field of contemporary psychology, and identifies the presuppositions that underlie this discipline. As a Christian, he looks beyond the dilemmas of modern psychology and sees hope -- for humanity and for "the science of human behavior." The Rebuilding of Psychology makes a bold proposal for rebuilding psychology on the theistic premise that "God exists and is the source of all truth." - Back cover.

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

Apoptosis is now widely recognized as a common form of cell death and represents a mechanism of cell clearance in many physiological situations where deletion of cells is required. Peptide growth factors, initially characterised as stimulators of cell proliferation, have now been shown to inhibit death in many cell types. Deprivation of growth factors leads to the induction of apoptosis, i.e. condensation of chromatin and degradation in oligonucleosomesized fragments, formation of plasma and nuclear membrane blebs and cell fragmentation into apoptotic (...) bodies which can be taken up by neighbouring cells. Here we discuss the mechanism(;s) by which growth factors may inhibit apoptosis. (shrink)

A. P. Martinich's The Two Gods of Leviathan appeared in 1992, and J. R. Collins's The Allegiance of Thomas Hobbes in 2005. Martinich offered a revisionist interpretation of Thomas Hobbes's religious commitments. He rebuked the conventional view that Hobbes was an atheist and placed him within particular traditions of reformed Christian theology. Collins's book strongly differed from these conclusions, and reasserted Hobbes's hostility to traditional Christianity as part of a general contextualization of his writings within the period of (...) the English Revolution. The following exchange between Martinich and Collins was first aired in 2007 as a debate at the Southwestern Political Science Association's Annual Conference. (shrink)

Research suggests political identity has strong influence over individuals’ attitudes and beliefs, which in turn can affect their behavior. Likewise, firsthand experience with an issue can also affect attitudes and beliefs. A large survey of Americans was analyzed to investigate the effects of both political identity and personal impact on individuals’ reactions to the COVID-19 pandemic. Results show that political identity and personal impact influenced the American public’s attitudes about and response to COVID-19. Consistent with prior research, political identity exerted (...) a strong influence on self-reports of emotional distress, threat perception, discomfort with exposure, support for restrictions, and perception of under/overreaction by individuals and institutions. The difference between Democrats and Republican responses were consistent with their normative value differences and with the contemporary partisan messaging. Personal impact exerted a comparatively weaker influence on reported emotional distress and threat perception. Both factors had a weak influence on appraisal of individual and government responses. The dominating influence of political identity carried over into the bivariate relations among these self-reported attitudes and responses. In particular, the appraisal of government response divided along party lines, tied to opposing views of whether there has been over- or under-reaction to the pandemic. The dominance of political identity has important implications for crisis management and reflects the influence of normative value differences between the parties, partisan messaging on the pandemic, and polarization in American politics. (shrink)

The Allegiance of Thomas Hobbes offers a new interpretation of Thomas Hobbes's response to the English Revolution. By focusing on his religious thought, it debunks the standard view of him as a royalist, and recovers his sympathies with the religious projects of the 1640s and 1650s. This reinterpretation culminates with an exploration of Hobbes's surprising sympathies with Oliver Cromwell and his supporters. By placing Thomas Hobbes within fresh contexts, Professor Collins offers a new angle of vision on the religious (...) significance of the English Revolution itself. (shrink)

Laws of mechanics, quantum mechanics, electromagnetism, gravitation and relativity are derived as “related mathematical identities” based solely on the existence of a joint probability distribution for the position and velocity of a particle moving on a Riemannian manifold. This probability formalism is necessary because continuous variables are not precisely observable. These demonstrations explain why these laws must have the forms previously discovered through experiment and empirical deduction. Indeed, the very existence of electric, magnetic and gravitational fields is predicted by these (...) purely mathematical constructions. Furthermore these constructions incorporate gravitation into special relativity theory and provide corrected definitions for coordinate time and proper time. These constructions then provide new insight into the relationship between manifold geometry and gravitation and present an alternative to Einstein’s general relativity theory. (shrink)

By 2014, each of the fifty states and the District of Columbia will have a new health insurance exchange, or marketplace, established under the Patient Protection and Affordable Care Act. These exchanges are the centerpiece of the reform law: they will be the main portals where people who do not have health insurance coverage through their jobs and small businesses will go, either in person or online, to find a health plan and to learn about and apply for federal subsidies. (...) The most immediate challenge facing all fifty‐one exchanges is fulfilling their most basic role: ensuring that all who are eligible to enroll in qualified health plans and to receive federal subsidies in fact enroll. (shrink)

One cannot but notice Plato's interest in prophecy and divination. He speaks disparagingly of the art and of those who practised it, yet it seems to have held some fascination for him. Moreover, he frequently uses the language of prophecy in a metaphorical sense, and it is this which I am to examine. Often, of course, this use is facetious, especially with the nouns ‘prophet’ and ‘prophecy’: he is ridiculing obscurity or playfully lending dignity to an obvious inference. But I (...) suggest that this facetious usage is common enough to be in itself evidence for the familiarity of Plato with this way of thinking. (shrink)

A new approach to developing formulisms of physics based solely on laws of mathematics is presented. From simple, classical statistical definitions for the observed space-time position and proper velocity of a particle having a discrete spectrum of internal states we derive u generalized Schrödinger equation on the space-time manifold. This governs the evolution of an N component wave function with each component square integrable over this manifold and is structured like that for a charged particle in an electromagnetic field but (...) also includes SU(N) gauge field couplings. This construction reveals a new hasis for gauge invariance and new insight into the appearance of spin and other such properties in relativistic quantum mechanics and suggests a new charged particle model. (shrink)

A relativistic one-particle, quantum theory for spin-zero particles is constructed uponL 2(x, ct), resulting in a positive definite spacetime probability density. A generalized Schrödinger equation having a Hermitian HamiltonianH onL 2(x, ct) for an arbitrary four-vector potential is derived. In this formalism the rest mass is an observable and a scalar particle is described by a wave packet that is a superposition of mass states. The requirements of macroscopic causality are shown to be satisfied by the most probable trajectory of (...) a free tardyon and a nontrivial framework for charged and neutral particles is provided. The Klein paradox is resolved and a link to the free particle field operators of quantum field theory is established. A charged particle interacting with a static magnetic field is discussed as an example of the formalism. (shrink)

Oxidised bases, such as 8-oxo-guanine, occur in cellular DNA as a result of attack by oxygen free radicals. The cancer-protective effect of vegetables and fruit is attributed to the ability of antioxidants in them to scavenge free radicals, preventing DNA damage and subsequent mutation. Antioxidant supplements (e.g., β-carotene, vitamin C) increase the resistance of lymphocytes to oxidative damage, and a negative correlation is seen between antioxidant concentrations in tissues and oxidised bases in DNA. Large-scale intervention trials with β-carotene have, however, (...) led to increases in cancer. Recent measurements of the frequency of oxidised DNA bases indicate that earlier estimates were greatly exaggerated; there may be only a few thousand 8-oxo-guanines per cell. Convincing evidence for mutations resulting from oxidative damage, in tumours or cultured cells, is lacking. It seems that efficient antioxidant defences together with DNA repair maintain a steady-state level of damage representing minimal risk to cell or organism. BioEssays 21:238–246, 1999. © 1999 John Wiley & Sons, Inc. (shrink)

To challenge the Foucauldian legacy of Jeremy Bentham’s panopticon prison, scholars often highlight Bentham’s later writings on the democratic power of public opinion. In doing so, they reaffirm Bentham’s reputation as a unreserved proponent of transparency. To recover the limits of Bentham’s embrace of publicity, I examine the model of visibility exemplified by his designs for the Sotimion, a residence for unmarried, pregnant women. The Sotimion draws our attention to Bentham’s appreciation for concealment as a method of preventing individual and (...) social harms caused by publicity and his criticisms of ascetic sexual norms. By being able to see visitors without being seen by them, the residents of the Sotimion would have avoided social censure while continuing to meet with friends, family, and even lovers. The Sotimion designs eschewed the panoptic principle, the use of asymmetric surveillance to reform moral behavior, and offered what I call the “soteric principle,” the use of asymmetric surveillance to protect the observer from punishment. By comparing the Sotimion to the Magdalen Hospital for Penitent Prostitutes and Bentham’s discussions of panoptic institutions for women, I examine the Sotimion’s distinctiveness while acknowledging its normalizing effects for residents from lower socioeconomic classes. Just as the panopticon captured Bentham’s commitment to publicity, applying the soteric model to Bentham’s theory of public opinion highlights his commitment to secrecy for protecting critics of government abuses from retribution. (shrink)

Desmosomes are junctions involved in intercellular adhesion of epithelial cells and hemidesmosomes are junctions involved in adhesion of epithelia to basement membranes. Both are characterised at the ultrastructural level by dense cytoplasmic plaques which are linked to the intermediate filament cytoskeleton of the cells. The plaques strongly resemble each other suggesting a relationship between the two kinds of junctions, as implied by their names. Recent characterisation of the molecular components of the junctions shows they are, in fact, quite unrelated implying (...) that structural similarity is fortuitous. The molecular biology raises many fascinating problems relating to their structure and function. (shrink)

Recent debates between modernists and postmodernists have shaken the foundations of modern social science. The epistemological assumptions of long-established procedures for constructing and validating knowledge claims have been called into question. This article discusses how two major contributors to the “new feminist epistemologies”—Dorothy Smith and Patricia Hill Collins—selectively integrate premises of modernist and postmodernist thought into their standpoint approaches. However, the particular premises they select result in significant ontological and epistemological differences between their works. These differences reflect major controversies (...) over materialism versus idealism, as well as essentialism versus diversity. As such, these different standpoints have important implications for feminist scholarship and political practice. (shrink)

James Collins has turned his talent for painstaking and definitive scholarship to the philosophy of religion, and nobody with an interest in this particular area of philosophy, or in the general development of modern philosophy in the hands of Hume, Kant, and Hegel, can afford to miss consulting this book. The philosophy of religion, as distinct from the older style natural theology, theodicy, and straight theological treatments of religion, is a discipline whose need was first felt when the scientific (...) picture of the universe began to declare its independence from, and possible ascendency over, the theistically ordered anthropological and cosmological harmony of the universe. As Collins details in a balanced manner, it was Hume who first formulated a program to meet this need. He did it in such a way, however, that he made religion a legitimate object of, but wholly external and even inimical in content to, philosophy, particularly epistemology and ethics. Building upon Hume, Kant defined the epistemological issue more precisely—"I have denied knowledge to save belief"—and reinterpreted the relation between morality and religion as one of complementarity rather than contradictoriness. It remained for Hegel to internalize the relation between the content of religion and the content of philosophy and thus to reduce the former to an anticipation of the latter. Collins' exposition is interpenetrated by a critical concern supplied by the dialectical development of the idea of the philosophy of religion from Hume through Kant to Hegel, and by his own proposal for integrating the genuine and irreducible insights of each of these three classical philosophies within a realistic philosophy of religion that remains basically theistic. The book is an expanded form of Collins' St. Thomas More Lectures at Yale University; it would be an impressive addition to any series of lectures.—E. A. R. (shrink)

The informed consent process is the legal embodiment of the fundamental right of the individual to make decisions affecting his or her health., and the patient’s permission is a crucial form of respect of freedom and dignity, it becomes extremely important to enhance the patient’s understanding and recall of the information given by the physician. This statement acquires additional weight when the medical treatment proposed can potentially be detrimental or even fatal. This is the case of thalassemia patients pertaining to (...) class 3 of the Pesaro classification where Allogenic hematopoietic stem cell transplantation remains the only potentially curative treatment. Unfortunately, this kind of intervention is burdened by an elevated transplantation-related mortality risk , equal to 30% according to published reports. In thalassemia, the role of the patient in the informed consent process leading up to HSCT has not been fully investigated. This study investigated the hypothesis that information provided by physicians in the medical scenario of HSCT is not fully understood by patients and that misunderstanding and communication biases may affect the clinical decision-making process. (shrink)

A. Collins once argued that time travel is only imaginable if we relate the "event" out of context. John Hospers argues that it is logically possible for an iron bar to float in water even if it is actually (empirically) impossible. My point in this piece is that Hospers relies on viewing the floating out of context, in Walt Disney fashion; but that is no way to establish any kind of possibility. I also discuss "conceivability", a term frequently used (...) either to clarify logical possibility or to interchange for the same. I argue that it cannot do either. (shrink)